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Illuminating the Role of Vitamin A in Skin Innate Immunity and the Skin Microbiome: A Narrative Review

Journal

NUTRIENTS
Volume 13, Issue 2, Pages -

Publisher

MDPI
DOI: 10.3390/nu13020302

Keywords

vitamin A; retinoic acid; skin immunity; innate immunity; skin microbiome

Funding

  1. Dermatology Foundation Diversity Supplement Award

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Vitamin A is crucial for skin immunity, deficiencies can lead to impaired immune response and increased susceptibility to skin infections. Recent evidence shows that vitamin A and its derivatives play a role in innate immune regulation by promoting skin immunity and sustaining the skin microbiome.
Vitamin A is a fat-soluble vitamin that plays an important role in skin immunity. Deficiencies in Vitamin A have been linked to impaired immune response and increased susceptibility to skin infections and inflammatory skin disease. This narrative review summarizes recent primary evidence that elucidates the role of vitamin A and its derivatives on innate immune regulators through mechanisms that promote skin immunity and sustain the skin microbiome.

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