Journal
NUTRIENTS
Volume 13, Issue 2, Pages -Publisher
MDPI
DOI: 10.3390/nu13020292
Keywords
phosphaturia; phosphate intake; FGF23; PTH; CKD
Categories
Funding
- Spanish government grant from the Programa Nacional I+D+I 2013-2016
- Instituto de Salud Carlos III (ISCIII) from European Funds (FEDER) [PI18/0138, PI17/01010]
- Consejeria de Salud
- EUTOX from the ISCIII
- REDinREN from the ISCIII
- Nicolas Monardes Programme, Consejeria de Salud-Servicio Andaluz de Salud (Junta de Andalucia)
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The study aimed to investigate the role of the P/UUN ratio in identifying patients with high inorganic phosphate intake, and found that the ratio can serve as a marker for inorganic phosphate intake. Patients with the highest P/UUN ratio were found to have a higher intake of inorganic phosphate.
In chronic kidney disease (CKD) patients, it would be desirable to reduce the intake of inorganic phosphate (P) rather than limit the intake of P contained in proteins. Urinary excretion of P should reflect intestinal absorption of P(inorganic plus protein-derived). The aim of the present study is to determine whether the ratio of urinary P to urinary urea nitrogen (P/UUN ratio) helps identify patients with a high intake of inorganic P.A cross-sectional study was performed in 71 patients affected by metabolic syndrome with CKD (stages 2-3) with normal serum P concentration. A 3-day dietary survey was performed to estimate the average daily amount and the source of P ingested. The daily intake of P was 1086.5 +/- 361.3 mg/day; 64% contained in animal proteins, 22% in vegetable proteins, and 14% as inorganic P. The total amount of P ingested did not correlate with daily phosphaturia, but it did correlate with the P/UUN ratio (p < 0.018). Patients with the highest tertile of the P/UUN ratio >71.1 mg/g presented more abundant inorganic P intake (p < 0.038).The P/UUN ratio is suggested to be a marker of inorganic P intake. This finding might be useful in clinical practices to identify the source of dietary P and to make personalized dietary recommendations directed to reduce inorganic P intake.
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