Journal
NUTRIENTS
Volume 13, Issue 1, Pages -Publisher
MDPI
DOI: 10.3390/nu13010127
Keywords
vitamin D; 25-hydroxyvitamin D; HDL; monocyte percentage; MHR; inflammation
Categories
Funding
- Qatar University [QUST-2-CMED-2019-6]
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Low serum 25-hydroxyvitamin D levels are associated with altered lipid profiles, inflammation, and cardiometabolic risks in young healthy adults, particularly in populations with high rates of deficiency and insufficiency. The Monocyte to HDL-cholesterol ratio (MHR) has emerged as a potential novel marker of inflammation that could help predict cardiovascular diseases among this demographic.
Low serum 25-hydroxyvitamin D [25(OH)D] is linked to an altered lipid profile. Monocytes play an important role in inflammation and lipid metabolism. Recently, monocyte percentage to HDL-cholesterol ratio (MHR) has emerged as a novel marker of inflammation. We investigated the association between serum 25(OH)D concentrations and MHR and serum lipids in young healthy adults. Data from the Qatar Biobank were utilized to investigate the relation between serum 25(OH)D and inflammation and serum lipid concentrations in healthy Qatari adults using multivariate regression analysis. Prevalence of serum 25(OH)D concentrations <12 ng/mL (deficiency), 12-20 ng/mL (insufficiency), and >= 20 ng/mL (sufficiency) were 55.8%, 29.9%, and 14.3%, respectively. Serum 25(OH)D was significantly inversely associated with monocyte percentage, MHR, total cholesterol, LDL-cholesterol, and triacylglycerol in multivariable adjusted analysis. MHR could be a potential biomarker to predict cardiometabolic diseases among young healthy Qataris.
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