Journal
NUTRIENTS
Volume 13, Issue 1, Pages -Publisher
MDPI
DOI: 10.3390/nu13010094
Keywords
maternal diet; fiber; protection; offspring; hiperglycemia
Categories
Funding
- Garland Initiative for Vision - William K. Bowes Jr.
Ask authors/readers for more resources
Through a longitudinal study on Nile rats, we found that maternal intake of a high-fiber diet significantly reduces the risk of diet-induced diabetes in offspring, indicating a potential protective effect of a high-fiber diet that can be transmitted through generations.
Previous studies have reported that maternal malnutrition is linked to increased risk of developing type 2 diabetes in adulthood. Although several diabetic risk factors associated with early-life environment have been identified, protective factors remain elusive. Here, we conducted a longitudinal study with 671 Nile rats whereby we examined the interplay between early-life environment (maternal diet) and later-life environment (offspring diet) using opposing diets that induce or prevent diet-induced diabetes. Specifically, we modulated the early-life environment throughout oogenesis, pregnancy, and nursing by feeding Nile rat dams a lifelong high-fiber diet to investigate whether the offspring are protected from type 2 diabetes. We found that exposure to a high-fiber maternal diet prior to weaning significantly lowered the risk of diet-induced diabetes in the offspring. Interestingly, offspring consuming a high-fiber diet after weaning did not develop diet-induced diabetes, even when exposed to a diabetogenic maternal diet. Here, we provide the first evidence that the protective effect of a high-fiber diet can be transmitted to the offspring through the maternal diet, which has important implications in diabetes prevention.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available