Journal
NUTRIENTS
Volume 13, Issue 2, Pages -Publisher
MDPI
DOI: 10.3390/nu13020373
Keywords
endocannabinoid system; obesity; cannabinoid receptors; obesity pathogenesis; obesity genes
Categories
Ask authors/readers for more resources
The endocannabinoid system (ECS) plays a crucial role in regulating energy balance, promoting metabolism, food intake, and body homeostasis, with its overactivity possibly being related to obesity. Investigating the impact of genetic factors on ECS regulation in obesity pathogenesis and finding new therapeutic targets are essential in addressing the global issue of obesity.
The endocannabinoid system (ECS) is an endogenous signaling system formed by specific receptors (cannabinoid type 1 and type 2 (CB1 and CB2)), their endogenous ligands (endocannabinoids), and enzymes involved in their synthesis and degradation. The ECS, centrally and peripherally, is involved in various physiological processes, including regulation of energy balance, promotion of metabolic process, food intake, weight gain, promotion of fat accumulation in adipocytes, and regulation of body homeostasis; thus, its overactivity may be related to obesity. In this review, we try to explain the role of the ECS and the impact of genetic factors on endocannabinoid system modulation in the pathogenesis of obesity, which is a global and civilizational problem affecting the entire world population regardless of age. We also emphasize that the search for potential new targets for health assessment, treatment, and the development of possible therapies in obesity is of great importance.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available