Journal
JOURNAL OF COSMETIC DERMATOLOGY
Volume 20, Issue 9, Pages 3007-3010Publisher
WILEY
DOI: 10.1111/jocd.13953
Keywords
folate; Melanoma; serum; vitamin B12
Categories
Ask authors/readers for more resources
Serum levels of folate were found significantly lower in melanoma cases, especially in patients with metastatic disease, as compared to other malignancies and healthy subjects. However, no significant association was found between melanoma and serum vitamin B12 levels.
Background Vitamin B12 and folate are the major micronutrients that play significant roles in DNA synthesis. Epidemiological studies and clinical evidences displayed alterations in serum concentrations folate and of vitamin B12 in various human malignancies, yet their roles in patients with melanoma have yet to be understood. Objective To assess circulating vitamin B12 and folate concentrations of patients with melanoma and compare them with other malignant tumors and healthy subjects. Methods A total of 98 skin melanoma cases from university clinic were enrolled into the study. Serum vitamin B12 and folate concentrations were analyzed by electrochemiluminescence binding assay. Results Circulating levels of vitamin B12 in patients with melanoma were similar compared with other malignancies and healthy controls (P > .05). However, melanoma cases had significantly lower serum folate concentrations than healthy control group (P = .04). Melanoma patients with metastatic disease (P = .001) and with short history of disease (P = .05), and those who had active diseases in course of the study (P = .04) had low serum folate concentrations. Conclusion Serum levels of folate were found significantly lower in melanoma cases, and this association was stronger for patients with metastatic melanoma; however, no such association was found between melanoma and serum vitamin B12 levels.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available