Recent Advances in Copper Promoted Inert C(sp3)-H Functionalization

Copper-promoted inert C(sp(3))-H functionalization has gradually been developed as a nascent tool to establish categories of bonds, including C(sp(3))-C, C(sp(3))-N, C(sp(3))-O/S, and C(sp(3))-X bonds. However, there have been no reviews summarizing the latest advances in this domain. Herein, we review the main progress of copper-promoted inert C(sp(3))-H functionalization, covering the literature up to 2020 and classifying the works by the types of bonds formed. Reaction characteristics and proposed mechanisms of nearly all examples are presented and, in some cases, are comprehensively compared with those of literature precedents. In addition, an overview of the current development of this field is summarized and the future of this domain is discussed.

Automated summary

This article reviews the main progress of copper-promoted inert C(sp(3))-H functionalization in establishing different types of bonds, presenting reaction characteristics, proposed mechanisms, and future development trends in this field.