Journal
ACS CATALYSIS
Volume 10, Issue 24, Pages 14615-14623Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.0c04515
Keywords
oxidative coupling; phenol coupling; photocatalysis; tyrosine dimerization; cross-coupling
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Funding
- NSF [CHE1764298, 1S10RR023444, 1S10RR022442, CHE-0840438, CHE-0848460, 1S10OD011980, CHE-1827457, DGE-1845298]
- NIH [R35 GM131902]
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An oxidative photocatalytic method for phenol-phenol homo- and cross-coupling is described, and isolated yields of 16-97% are obtained. Measured oxidation potentials and computed nucleophilicity parameters support a mechanism of nucleophilic attack of one partner onto the oxidized neutral radical form of the other partner. Our understanding of this model permitted the development of cross-coupling reactions between nucleophilic phenols/arenes and easily oxidized phenols with high selectivity and efficiency. A highlight of this method is that one equivalent of each coupling partner is utilized. Building on these findings, a nonenzymatic, catalytic method for coupling tyrosine was also developed.
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