Journal
ACS CATALYSIS
Volume 11, Issue 1, Pages 193-198Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.0c04713
Keywords
vinylidenes; O-H bond insertion; cyclization; oxygen heterocycles; nickel catalysis
Categories
Funding
- NIH [R35 GM124791]
- Camille Dreyfus Teacher-Scholar award
- Lilly Grantee award
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The (pybox)Ni catalyst enables the reductive cyclization of beta-hydroxy 1,1-dichloroalkenes to form 2,3-dihydrofurans, providing a convenient method for the synthesis of stereochemically complex products. Chiral substrates can be accessed in highly enantioenriched form, with mechanistic studies supporting a vinylidene O-H insertion pathway.
A (pybox)Ni catalyst (where pybox = pyridine-bis(oxazoline)) promotes the reductive cyclization of beta-hydroxy 1,1-dichloroalkenes to form 2,3-dihydrofurans. The substrates for this reaction are conveniently prepared by an aldol addition, followed by one-carbon homologation. Chiral substrates are accessible in highly enantioenriched form, allowing for the synthesis of stereochemically complex 2,3,4-trisubstituted products. Mechanistic studies support a vinylidene O-H insertion rather than a C-O cross-coupling pathway.
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