Journal
NATURE COMMUNICATIONS
Volume 11, Issue 1, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41467-020-19945-w
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Funding
- National Key R&D Program of China [2020YFA0908800]
- NSFC [81773674, 81573383]
- Shenzhen Science and Technology Research Grant [JCYJ20190808152019182]
- National Natural Science Foundation of Hubei Province [2017CFA024, 2017CFB711]
- Applied Basic Research Program of Wuhan Municipal Bureau of Science and Technology [2019020701011429]
- Tibet Autonomous Region Science and Technology Plan Project Key Project [XZ201901-GB-11]
- Local Development Funds of Science and Technology Department of Tibet [XZ202001YD0028C]
- Chengdu University of Traditional Chinese Medicine [CZYJC1903]
- Health Commission of Hubei Province Scientific Research Project [WJ2019M177, WJ2019M178]
- China Scholarship Council
- Fundamental Research Funds for the Central Universities
- Hubei Province Scientific and Technical Innovation Key Project
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NIR-II fluorophores have shown great promise for biomedical applications with superior in vivo optical properties. To date, few small-molecule NIR-II fluorophores have been discovered with donor-acceptor-donor (D-A-D) or symmetrical structures, and upconversion-mitochondria-targeted NIR-II dyes have not been reported. Herein, we report development of D-A type thiopyrylium-based NIR-II fluorophores with frequency upconversion luminescence (FUCL) at similar to 580nm upon excitation at similar to 850nm. H4-PEG-PT can not only quickly and effectively image mitochondria in live or fixed osteosarcoma cells with subcellular resolution at 1nM, but also efficiently convert optical energy into heat, achieving mitochondria-targeted photothermal cancer therapy without ROS effects. H4-PEG-PT has been further evaluated in vivo and exhibited strong tumor uptake, specific NIR-II signals with high spatial and temporal resolution, and remarkable NIR-II image-guided photothermal therapy. This report presents the first D-A type thiopyrylium NIR-II theranostics for synchronous upconversion-mitochondria-targeted cell imaging, in vivo NIR-II osteosarcoma imaging and excellent photothermal efficiency. Currently available mitochondria-targeted fluorescent dyes emit only one color in the visible or NIR-I and their applications are limited. Here, the authors develop upconversion mitochondria-targeted NIR-II fluorophores for synchronous upconversion-mitochondria-targeted cell imaging, in vivo NIR-II osteosarcoma imaging and photothermal efficiency
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