Related references
Note: Only part of the references are listed.Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies
Hui Yi Chew et al.
CELL (2020)
Combining BH3-mimetics to target both BCL-2 and MCL1 has potent activity in pre-clinical models of acute myeloid leukemia
Donia M. Moujalled et al.
LEUKEMIA (2019)
Targeting Glioma Stem Cells by Functional Inhibition of Dynamin 2: A Novel Treatment Strategy for Glioblastoma
Rodney Luwor et al.
CANCER INVESTIGATION (2019)
N-Cadherin-Expressing Bone and Marrow Stromal Progenitor Cells Maintain Reserve Hematopoietic Stem Cells
Meng Zhao et al.
CELL REPORTS (2019)
Mutant JAK3 phosphoproteomic profiling predicts synergism between JAK3 inhibitors and MEK/BCL2 inhibitors for the treatment of T-cell acute lymphoblastic leukemia
S. Degryse et al.
LEUKEMIA (2018)
Mathematical modeling of the impact of cytokine response of acute myeloid leukemia cells on patient prognosis
Thomas Stiehl et al.
SCIENTIFIC REPORTS (2018)
Restricted cell cycle is essential for clonal evolution and therapeutic resistance of pre-leukemic stem cells
Cedric S. Tremblay et al.
NATURE COMMUNICATIONS (2018)
Dynamin impacts homology-directed repair and breast cancer response to chemotherapy
Sophia B. Chernikova et al.
JOURNAL OF CLINICAL INVESTIGATION (2018)
Improved multilineage human hematopoietic reconstitution and function in NSGS mice
Mark Wunderlich et al.
PLOS ONE (2018)
Dynamins 2 and 3 control the migration of human megakaryocytes by regulating CXCR4 surface expression and ITGB1 activity
Praveen K. Suraneni et al.
BLOOD ADVANCES (2018)
Dynamin-dependent amino acid endocytosis activates mechanistic target of rapamycin complex 1 (mTORC1)
Shusaku Shibutani et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2017)
Reciprocal regulation of signaling and endocytosis: Implications for the evolving cancer cell
Sandra L. Schmid
JOURNAL OF CELL BIOLOGY (2017)
JAK/STAT pathway inhibition overcomes IL7-induced glucocorticoid resistance in a subset of human T-cell acute lymphoblastic leukemias
C. Delgado-Martin et al.
LEUKEMIA (2017)
Cancer stem cells revisited
Eduard Batlle et al.
NATURE MEDICINE (2017)
From the outside, from within: Biological and therapeutic relevance of signal transduction in T-cell acute lymphoblastic leukemia
Mariana L. Oliveira et al.
CELLULAR SIGNALLING (2017)
IL-7 induces clathrin-mediated endocytosis of CD127 and subsequent degradation by the proteasome in primary human CD8 T cells
Elliott M. Faller et al.
IMMUNOLOGY AND CELL BIOLOGY (2016)
Characterization of Rare, Dormant, and Therapy-Resistant Cells in Acute Lymphoblastic Leukemia
Sarah Ebinger et al.
CANCER CELL (2016)
Loss-of-function mutations of Dynamin 2 promote T-ALL by enhancing IL-7 signalling
C. S. Tremblay et al.
LEUKEMIA (2016)
Genomic Classification and Prognosis in Acute Myeloid Leukemia
Elli Papaemmanuil et al.
NEW ENGLAND JOURNAL OF MEDICINE (2016)
IL-7 Receptor Mutations and Steroid Resistance in Pediatric T cell Acute Lymphoblastic Leukemia: A Genome Sequencing Study
Yunlei Li et al.
PLOS MEDICINE (2016)
Targeting High Dynamin-2 (DNM2) Expression by Restoring Ikaros Function in Acute Lymphoblastic Leukemia
Zheng Ge et al.
SCIENTIFIC REPORTS (2016)
AKR1C3 is a biomarker of sensitivity to PR-104 in preclinical models of T-cell acute lymphoblastic leukemia
Donya Moradi Manesh et al.
BLOOD (2015)
Efficacy of JAK/STAT pathway inhibition in murine xenograft models of early T-cell precursor (ETP) acute lymphoblastic leukemia
Shannon L. Maude et al.
BLOOD (2015)
Lymphotoxin-β receptor in microenvironmental cells promotes the development of T-cell acute lymphoblastic leukaemia with cortical/mature immunophenotype
Monica T. Fernandes et al.
BRITISH JOURNAL OF HAEMATOLOGY (2015)
CXCR4 Is Required for Leukemia-Initiating Cell Activity in T Cell Acute Lymphoblastic Leukemia
Diana Passaro et al.
CANCER CELL (2015)
CXCL12-Producing Vascular Endothelial Niches Control Acute T Cell Leukemia Maintenance
Lauren A. Pitt et al.
CANCER CELL (2015)
Endocytic Trafficking of Integrins in Cell Migration
Nikki R. Paul et al.
CURRENT BIOLOGY (2015)
Association Between Mutation Clearance After Induction Therapy and Outcomes in Acute Myeloid Leukemia
Jeffery M. Klco et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2015)
Small molecules demonstrate the role of dynamin as a bi-directional regulator of the exocytosis fusion pore and vesicle release
J. Jackson et al.
MOLECULAR PSYCHIATRY (2015)
Revised assessment of response and long-term discontinuation rates among 111 patients with myelofibrosis treated with momelotinib or ruxolitinib
R. A. Abdelrahman et al.
LEUKEMIA (2015)
Hhex regulates Kit to promote radioresistance of self-renewing thymocytes in Lmo2-transgenic mice
B. J. Shields et al.
LEUKEMIA (2015)
Molecular Pathways: Molecular Basis for Sensitivity and Resistance to JAK Kinase Inhibitors
Sara C. Meyer et al.
CLINICAL CANCER RESEARCH (2014)
The clonal evolution of leukemic stem cells in T-cell acute lymphoblastic leukemia
Cedric S. Tremblay et al.
CURRENT OPINION IN HEMATOLOGY (2014)
Cytokines secreted by bone marrow stromal cells protect c-KIT mutant AML cells from c-KIT inhibitor-induced apoptosis
P. M. Gordon et al.
LEUKEMIA (2014)
Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia
Liran I. Shlush et al.
NATURE (2014)
Hematopoietic stem cell niche maintenance during homeostasis and regeneration
Avital Mendelson et al.
NATURE MEDICINE (2014)
Identification of small molecules that support human leukemia stem cell activity ex vivo
Caroline Pabst et al.
NATURE METHODS (2014)
Synthesis of Dynole 34-2, Dynole 2-24 and Dyngo 4a for investigating dynamin GTPase
Mark J. Robertson et al.
NATURE PROTOCOLS (2014)
Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal
Iman Fares et al.
SCIENCE (2014)
SCL, LMO1 and Notch1 Reprogram Thymocytes into Self-Renewing Cells
Bastien Gerby et al.
PLOS GENETICS (2014)
The Src and c-Kit kinase inhibitor dasatinib enhances p53-mediated targeting of human acute myeloid leukemia stem cells by chemotherapeutic agents
Cedric Dos Santos et al.
BLOOD (2013)
AML cells are differentially sensitive to chemotherapy treatment in a human xenograft model
Mark Wunderlich et al.
BLOOD (2013)
Direct Reversal of Glucocorticoid Resistance by AKT Inhibition in Acute Lymphoblastic Leukemia
Erich Piovan et al.
CANCER CELL (2013)
Relapsed childhood acute lymphoblastic leukaemia
Deepa Bhojwani et al.
LANCET ONCOLOGY (2013)
Building a Better Dynasore: The Dyngo Compounds Potently Inhibit Dynamin and Endocytosis
Adam McCluskey et al.
TRAFFIC (2013)
Cancer drug resistance: an evolving paradigm
Caitriona Holohan et al.
NATURE REVIEWS CANCER (2013)
Imaging Tumor-Stroma Interactions during Chemotherapy Reveals Contributions of the Microenvironment to Resistance
Elizabeth S. Nakasone et al.
CANCER CELL (2012)
Using combination therapy to override stromal-mediated chemoresistance in mutant FLT3-positive AML: synergism between FLT3 inhibitors, dasatinib/multi-targeted inhibitors and JAK inhibitors
E. Weisberg et al.
LEUKEMIA (2012)
Hematopoietic stem cell mobilizing agents G-CSF, cyclophosphamide or AMD3100 have distinct mechanisms of action on bone marrow HSC niches and bone formation
I. G. Winkler et al.
LEUKEMIA (2012)
The genetic basis of early T-cell precursor acute lymphoblastic leukaemia
Jinghui Zhang et al.
NATURE (2012)
Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing
Li Ding et al.
NATURE (2012)
Pharmacokinetic Modeling of an Induction Regimen for In Vivo Combined Testing of Novel Drugs against Pediatric Acute Lymphoblastic Leukemia Xenografts
Barbara Szymanska et al.
PLOS ONE (2012)
NOTCH1 Signaling Promotes Human T-Cell Acute Lymphoblastic Leukemia Initiating Cell Regeneration in Supportive Niches
Wenxue Ma et al.
PLOS ONE (2012)
L-Asparaginase Treatment in Acute Lymphoblastic Leukemia
Rob Pieters et al.
CANCER (2011)
IL-7 Contributes to the Progression of Human T-cell Acute Lymphoblastic Leukemias
Ana Silva et al.
CANCER RESEARCH (2011)
Therapeutic potential of Notch inhibition in T-cell acute lymphoblastic leukemia: rationale, caveats and promises
Leonor M. Sarmento et al.
EXPERT REVIEW OF ANTICANCER THERAPY (2011)
Dynamin inhibitors induce caspase-mediated apoptosis following cytokinesis failure in human cancer cells and this is blocked by Bcl-2 overexpression
Sanket Joshi et al.
MOLECULAR CANCER (2011)
Inhibition of Dynamin by Dynole 34-2 Induces Cell Death following Cytokinesis Failure in Cancer Cells
Megan Chircop et al.
MOLECULAR CANCER THERAPEUTICS (2011)
Toolkit for evaluating genes required for proliferation and survival using tetracycline-regulated RNAi
Johannes Zuber et al.
NATURE BIOTECHNOLOGY (2011)
Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia
Priscila P. Zenatti et al.
NATURE GENETICS (2011)
Long-Term Outcome of Treatment with Ruxolitinib in Myelofibrosis
Ayalew Tefferi et al.
NEW ENGLAND JOURNAL OF MEDICINE (2011)
Further activation of FLT3 mutants by FLT3 ligand
R. Zheng et al.
ONCOGENE (2011)
High Cleavage Efficiency of a 2A Peptide Derived from Porcine Teschovirus-1 in Human Cell Lines, Zebrafish and Mice
Jin Hee Kim et al.
PLOS ONE (2011)
IL-7 induces rapid clathrin-mediated internalization and JAK3-dependent degradation of IL-7Rα in T cells
Catarina M. Henriques et al.
BLOOD (2010)
Modeling T-cell acute lymphoblastic leukemia induced by the SCL and LMO1 oncogenes
Mathieu Tremblay et al.
GENES & DEVELOPMENT (2010)
AML xenograft efficiency is significantly improved in NOD/SCID-IL2RG mice constitutively expressing human SCF, GM-CSF and IL-3
M. Wunderlich et al.
LEUKEMIA (2010)
The Lmo2 Oncogene Initiates Leukemia in Mice by Inducing Thymocyte Self-Renewal
Matthew P. McCormack et al.
SCIENCE (2010)
ELDA: Extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays
Yifang Hu et al.
JOURNAL OF IMMUNOLOGICAL METHODS (2009)
Inhibition of Dynamin Mediated Endocytosis by the Dynoles-Synthesis and Functional Activity of a Family of Indoles
Timothy A. Hill et al.
JOURNAL OF MEDICINAL CHEMISTRY (2009)
Endocytosis and signalling: intertwining molecular networks
Alexander Sorkin et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2009)
Genomic Analysis of the Clonal Origins of Relapsed Acute Lymphoblastic Leukemia
Charles G. Mullighan et al.
SCIENCE (2008)
CXCR4 antagonists mobilize childhood acute lymphoblastic leukemia cells into the peripheral blood and inhibit engraftment
J. Juarez et al.
LEUKEMIA (2007)
Prolonged exposure to FLT3 inhibitors leads to resistance via activation of parallel signaling pathways
Obdulio Piloto et al.
BLOOD (2007)
The role of Notch and IL-7 signaling in early thymocyte proliferation and differentiation
G Balciunaite et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2005)
NOD/SCID mice engineered to express human IL-3, GM-CSF and Steel factor constitutively mobilize engrafted human progenitors and compromise human stem cell regeneration
FE Nicolini et al.
LEUKEMIA (2004)
Characterization of childhood acute lymphoblastic leukemia xenograft models for the preclinical evaluation of new therapies
NLM Liem et al.
BLOOD (2004)
Distinct effects of STAT5 activation on CD4+ and CD8+ T cell homeostasis:: Development of CD4+CD25+ regulatory T cells versus CD8+ memory T cells
MA Burchill et al.
JOURNAL OF IMMUNOLOGY (2003)
Induction of T cell development from hematopoietic progenitor cells by delta-like-1 in vitro
TM Schmitt et al.
IMMUNITY (2002)
Elevated expression of IL-3Rα in acute myelogenous leukemia is associated with enhanced blast proliferation, increased cellularity, and poor prognosis
U Testa et al.
BLOOD (2002)
A reassessment of the effect of activated Notch1 on CD4 and CD8 T cell development
BJ Fowlkes et al.
JOURNAL OF IMMUNOLOGY (2002)
The nonobese diabetic/severe combined immunodeficient (NOD/SCID) mouse model of childhood acute lymphoblastic leukemia reveals intrinsic differences in biologic characteristics at diagnosis and relapse
RB Lock et al.
BLOOD (2002)
Dynamin:GTP controls the formation of constricted coated pits, the rate limiting step in clathrin-mediated endocytosis
S Sever et al.
JOURNAL OF CELL BIOLOGY (2000)