Chemical Biology in Auxin Research

Molecular genetic and structural studies have revealed the mechanisms of fundamental components of key auxin regulatory pathways consisting of auxin biosynthesis, transport, and signaling. Chemical biology methods applied in auxin research have been greatly expanded through the understanding of auxin regulatory pathways. Many small-molecule modulators of auxin metabolism, transport, and signaling have been generated on the basis of the outcomes of genetic and structural studies on auxin regulatory pathways. These chemical modulators are now widely used as essential tools for dissecting auxin biology in diverse plants. This review covers the structures, primary targets, modes of action, and applications of chemical tools in auxin biosynthesis, transport, and signaling.

Automated summary

Recent molecular genetic and structural studies have provided insights into the regulatory pathways of plant hormones, expanding the application of chemical biology methods in auxin research. Small-molecule modulators generated based on studies of auxin regulatory pathways are now widely used in dissecting auxin biology in diverse plants.