Journal
MBIO
Volume 11, Issue 6, Pages -Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/mBio.03126-20
Keywords
Listeria monocytogenes; virulence heterogeneity; hypervirulent strains; prolonged in vivo survival; invasive listeriosis; in vivo survival; maternal-fetal listeriosis; neurolisteriosis
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Funding
- Spanish Ministry for Science and Technology [BMC2000-0553]
- Welcome Trust [WT074020MA]
- Austrian Science Fund [J-1694]
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Although all isolates of the foodborne pathogen Listeria monocytogenes are considered to be pathogenic, epidemiological evidence indicates that certain serovar 4b lineages are more likely to cause severe invasive (neuromeningeal, maternal-fetal) listeriosis. Recently described as L. monocytogenes hypervirulent clones, no distinctive bacterial trait has been identified so far that could account for the differential pathogenicity of these strains. Here, we discuss some preliminary observations in experimentally infected mice suggesting that serovar 4b hypervirulent strains may have a hitherto unrecognized capacity for prolonged in vivo survival. We propose the hypothesis that protracted survivability in primary infection foci in liver and spleen -the first target organs after intestinal translocation-may cause L. monocytogenes serovar 4b hypervirulent clones to have a higher probability of secondary dissemination to brain and placenta.
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