4.7 Article

Sulfated Mesona chinensis Benth polysaccharide enhance the immunomodulatory activities of cyclophosphamide-treated mice

Journal

JOURNAL OF FUNCTIONAL FOODS
Volume 76, Issue -, Pages -

Publisher

ELSEVIER
DOI: 10.1016/j.jff.2020.104321

Keywords

Mesona chinensis Benth; Sulfated polysaccharide; Immunomodulatory activity

Funding

  1. Research Project of State Key Laboratory of Food Science and Technology, Nanchang University, China [SKLF-ZZB-201917]
  2. National Youth Talent Support Program of China

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The sulfated polysaccharide (SMP) from Mesona chinensis Benth exhibits immunomodulatory effects by inducing various immune responses and improving antioxidant capacity. The SMP can be used as functional foods for its beneficial effects on immune regulation and overall health.
A sulfated polysaccharide (SMP) from the Mesona chinensis Benth was successfully obtained and its immunomodulatory effects were evaluated. Results showed that SMP exhibited the proliferation effects in splenocytes in vitro and ameliorated the impaired of splenocytes in Cy-treated mice. SMP induced the production of nitric oxide (NO), interleukin (IL) -2, interferon-gamma (IFN-gamma), increased the expression of antioxidant enzymes (SOD and CAT), and reduced the production of malondialdehyde (MDA) in Cy-treated mice, as well as improved the blood index, body weight and organ index. In addition, SMP enhanced the viability of RAW264.7 macrophages and increased the secretion of IL-6, IL-1 beta and tumor necrosis factor-alpha (TNF-alpha) and production of NO in RAW264.7 cells. Furthermore, SMP binds to TLR4 (Toll-like Receptor 4) to promote RAW264.7 to produce cytokines, thereby exerting immunoregulatory function. These data indicated that SMP act a pivotal part in immunomodulatory and could be used as functional foods.

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