Journal
ONCOTARGETS AND THERAPY
Volume 13, Issue -, Pages 12587-12599Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/OTT.S281328
Keywords
Huaier; antineoplastic mechanisms; breast cancer; gastric cancer; liver cancer; pulmonary cancer
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Funding
- Chen Xiao-ping Foundation for the Development of Science and Technology of Hubei Province, China [CXPJJH11900002-072]
- Shanxi Province Science and Technology Department [20090311061]
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Huaier (Trametes robiniophila Murr), a Chinese traditional herb of medicine, has demonstrated promising curative effects in clinical treatment for various tumors. There are documented experiments showing the biological functions of Huaier with its antineoplastic molecular mechanisms: restraining proliferation and metastasis, arresting cell cycle, inducing apoptosis, pyrosis, and autophagy, anti-intratumoral angiogenesis, attenuating characteristics of tumor stem-like cells, interfering with the function of the tumor-related immune system, reversing drug resistance, and enhancing the sensitivity to chemotherapeutic drugs, etc. In addition, studies suggest that non-coding RNA (ncRNA) acts a pivotal part in cancer occurrence and development, and demonstrates that Huaier adjusts the performance of certain lncRNA (long non-coding RNA) and proceeds to affect the microRNA and its target genes, rendering an anti-tumor effect. Huaier also modulates the expression of lncRNA to attenuate the activity of ncRNA-sponged microRNA and then inhibits the expression of downstream target genes. We summarize and illustrate the experimentally confirmed anticancer molecular mechanisms of Huaier, to inspire new ideas for researchers in relevant fields.
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