Journal
VIRUSES-BASEL
Volume 13, Issue 1, Pages -Publisher
MDPI
DOI: 10.3390/v13010040
Keywords
SARS-CoV-2; COVID-19; diagnostic; molecular testing; serology testing
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Diagnostic tests are crucial for controlling COVID-19, with nucleic acid-based tests for initial virus detection and serological tests for disease progression assessment. Test performance varies based on factors like sample type and assay characteristics, with positivity linked to symptom onset. Point-of-care testing is a cost-effective trend, but analytical performance must be carefully evaluated.
Diagnostic tests have been considered as the main alternative for the control of coronavirus disease (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), as a correct diagnosis allows for decision making when facing the disease, particularly as there is a lack of effective therapeutic protocols and vaccines. Thus, in this review, we summarized the main diagnostic approaches currently available for the diagnosis of SARS-CoV-2 infection in humans based on studies available in article databases. The tests can be organized into two main categories: nucleic acid-based tests, recommended for the initial detection of the virus, and serological tests, recommended for assessing the disease progression. The studies have shown that the performance of diagnostic methods depends on different factors, such as the type of samples and the characteristics of each assay. It was identified that the positivity of the tests is mainly related to the onset of symptoms. We also observed that point-of-care diagnoses are considered as one of the main trends in this area, due to the low-cost and simplicity of the assay; however, the analytical performance must be critically analyzed. Thus, the COVID-19 pandemic has highlighted the critical role of diagnostic technologies in the control of infectious diseases.
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