Echocardiographic correlates of severe pulmonary hypertension in adult patients with ostium secundum atrial septal defect

Objective: To identify echocardiographic factors that correlate with pulmonary hypertension (PH) in adults with ostium secundum atrial septal defect (ASD). Methods: Between November 2009 and November 2013, 92 adults with ASD were studied. All had clinical history and transthoracic echocardiogram. Results: Thirty-nine percent of patients had severe PH defined as systolic pulmonary artery pressure (sPAP) of 70 mm Hg or more. The size of ASD (31.84+/-8.21 mm) and a right-sided tricuspid inflow E-wave to tissue Doppler e'-wave ratio > 6.2 correlated with severe PH with AUC of 0.704 (CI 95%=0.59 to 0.818, P<.001) and 0.65 (CI 95%=0.531 to 0.773, P<.014), respectively. Multivariate logistic regression showed that sPAP > 70 mm Hg was the variable that most precisely correlated with right ventricular (RV) dysfunction as evidenced by TAPSE < 17 mm and RV fractional shortening area (RVFSA) < 35%. Left ventricular (LV) diastolic function was also significantly reduced in the group with severe PH with mitral inflow E/A ratio of 0.73+/-0.23 vs 1.13+/-0.42 in the group without severe PH (sPAP < 70 mm Hg, (P=.001). The pulmonary (Qp) to systemic (Qs) cardiac output ratio (3.09+/-1.12) and right-sided tissue Doppler S < 9.5 cm/s most accurately predicted a Tei index >0.55. Conclusions: Larger size of ASD using the QP/QS ratio and increased right-sided tricuspid E/e' ratio correlated with severe PH with a sPAP of 70 mm Hg or more. Patients with severe PH had more severe RV dysfunction as evaluated by TAPSE and RVFSA in comparison to those with PH < 70 mm Hg. LV diastolic function was also reduced in the severe PH group.