Journal
VACCINE
Volume 39, Issue 2, Pages 402-411Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2020.11.041
Keywords
Antibodies; Microneutralization test; Humoral immunity; Influenza A(H5N1); Pre-pandemic vaccine
Categories
Funding
- Finnish Institute for Health and Welfare (THL)
- Ministry of Social Affairs and Health (Finland)
- Identification of Mechanisms Correlating with Susceptibility for Avian Influenza (IMECS) project by the European Commission, DG Research [201169]
Ask authors/readers for more resources
The study found that sequential vaccination with two different H5N1 vaccines can induce long-lasting high level cross-subtype immunity, supporting a prime-boost vaccination strategy in vaccination plans.
Background: Avian influenza A(H5N1) viruses have caused sporadic infections in humans and thus they pose a significant global health threat. Among symptomatic patients the case fatality rate has been ca. 50%. H5N1 viruses exist in multiple clades and subclades and several candidate vaccines have been developed to prevent A(H5N1) infection as a principal measure for preventing the disease. Methods: Serum antibodies against various influenza A(H5N1) Glade viruses were measured in adults by ELISA-based microneutralization and haemagglutination inhibition tests before and after vaccination with two different A(H5N1) vaccines in 2009 and 2011. Results: Two doses of AS03-adjuvanted A/Indonesia/5/2005 vaccine induced good homologous but poor heterologous neutralizing antibody responses against different Glade viruses. However, non-adjuvanted A/Vietnam/1203/2004 booster vaccination in 2011 induced very strong and long-lasting homologous and heterologous antibody responses while homologous response remained weak in naive subjects. Conclusions: Sequential vaccination with two different A(H5N1) pre-pandemic vaccines induced long-lasting high level cross-Glade immunity against influenza A(H5N1) strains, thus supporting a prime-boost vaccination strategy in pandemic preparedness plans. (C) 2020 The Author(s). Published by Elsevier Ltd.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available