Immunogenicity, safety and reactogenicity of ROTAVAC® in healthy infants aged 6-8 weeks in Vietnam

Background: ROTAVAC (R) is derived from human 116E rotavirus (RV) neonatal strain. In this study, we evaluated the immunogenicity, safety and reactogenicity of ROTAVAC (R) in Vietnam. Method: We conducted a phase IV clinical trial in healthy infants aged 6-8 weeks using the complete regimen of ROTAVAC (R) with three doses. Serum anti-RV IgA was measured by enzyme-linked immunosorbent assay to assess the geometric mean concentration in infants who received the complete regimen of the vaccine. Results: A total of 360 participants were enrolled in this clinical trial. The mean age +/- standard deviation at enrollment was 6.9 +/- 0.6 weeks. The anti-RV IgA titer was 4.01 +/- 3.74 mg/ml pre-vaccination and substantially increased to 29.27 +/- 80.64 mg/ml post-vaccination. The value of loglgA significantly increased (p = 0.003) from 0.28 +/- 0.79 to 1.03 +/- 0.54. The proportion of participants with equal to and greater than 3-fold and 4-fold shifts in pre- to post-vaccination antibody titer (IgA) were 55.4% and 48.3%, respectively. No adverse events or serious adverse events were recorded immediately within 30 min after the administration of each dose. The most common adverse events within 14 days after each visit were fever, unusual crying and irritability. Other adverse events occurred at a low rate, and no case of intus-susception was noted. Conclusions: The complete regimen of ROTAVAC (R) demonstrated an immunological response with clinically acceptable safety profile. Post-completion of this study, ROTAVAC (R) is now a WHO-prequalified vaccine and available in Vietnam. (C) 2021 Elsevier Ltd. All rights reserved.

Automated summary

The study in Vietnam evaluated the immunogenicity, safety, and reactogenicity of ROTAVAC (R) in 360 healthy infants. The vaccine regimen demonstrated an immunological response with clinically acceptable safety profile, with only minor adverse events recorded.