Journal
ULTRASOUND IN MEDICINE AND BIOLOGY
Volume 47, Issue 4, Pages 869-879Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ultrasmedbio.2020.12.020
Keywords
Contrast-enhanced ultrasound; Lymphadenopathy; Meta-analysis
Funding
- Science and Technology Department of Sichuan province [2018 JY0165]
- West China Hospital, Sichuan University [HXFH052]
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This meta-analysis showed that CEUS has high sensitivity and specificity in identifying lymphadenopathy, indicating its potential value in providing clinical decision support.
This meta-analysis aimed to evaluate the diagnostic accuracy of contrast-enhanced ultrasonography (CEUS) in identifying lymphazdenopathy. PubMed, Web of Science, Embase and the Cochrane Library were searched for relevant articles through September 2020. A total of 16 articles, which included 1787 participants, were analyzed. The summary sensitivity, specificity, positive likelihood ratio (LR), negative LR and diagnostic odds ratio of CEUS for diagnosing lymphadenopathy were 0.88 (0.86-0.90), 0.90 (0.88-0.92), 6.04 (3.67-9.95), 0.15 (0.10-0.21) and 47.38 (23.45-95.66), respectively. The summary receiver operating characteristic (SROC) area under the curve (AUC) was 0.9405. After omitting outliers identified in a bivariate box plot and forest plot, heterogeneity was decreased, and the pooled sensitivity and specificity were 0.87 (0.84- 0.90) and 0.87 (0.84- 0.90), respectively. Furthermore, the SROC AUC was 0.9327. In conclusion, CEUS has the potential to be a valuable tool for characterizing lymphadenopathy and could provide clinical decision support. (E-mail: drmaxuelei@gmail.com) (C) 2020 World Federation for Ultrasound in Medicine & Biology. All rights reserved.
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