Blood-Brain Barrier Dynamics to Maintain Brain Homeostasis

The blood?brain barrier (BBB) is a dynamic platform for exchange of substances between the blood and the brain parenchyma, and it is an essential functional gatekeeper for the central nervous system (CNS). While it is widely recognized that BBB disruption is a hallmark of several neurovascular pathologies, an aspect of the BBB that has received somewhat less attention is the dynamic modulation of BBB tightness to maintain brain homeostasis in response to extrinsic environmental factors and physiological changes. In this review, we summarize how BBB integrity adjusts in critical stages along the life span, as well as how BBB permeability can be altered by common stressors derived from nutritional habits, environmental factors and psychological stress.

Automated summary

The blood-brain barrier (BBB) is a critical gatekeeper between the blood and the brain parenchyma, maintaining brain homeostasis by dynamically adjusting its tightness. BBB integrity is adjusted at critical stages in life and can be influenced by stressors such as nutrition, environment, and psychological stress.