Journal
TRENDS IN GENETICS
Volume 37, Issue 5, Pages 460-475Publisher
CELL PRESS
DOI: 10.1016/j.tig.2020.11.003
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Funding
- Ministere francais de l'Enseignement superieur, de la Recherche et de l'Innovation fellowship
- Fondation ARC pour la recherche sur le cancer
- CNRS
- University of Paris
- Commissariat a l'Energie Atomique et aux Energies Alternatives
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FOX proteins belong to a conserved family of transcription factors that have evolved through gene/genome duplication, showing both functional redundancy and specific roles in development and adulthood. Genetic alterations or misregulation of FOX genes can lead to human genetic diseases, cancer, and/or aging. This review provides an updated overview of the characteristics of FOX family members in terms of expression, protein domain composition, evolution, and function.
Forkhead box (FOX) proteins belong to an evolutionarily conserved family of transcription factors that has evolved by gene/genome duplication. FOX family members have undergone sequence and regulatory diversification. However, they have retained some degree of functional redundancy, in addition to playing specific roles, both during development and in the adult. Genetic alterations or misregulation of FOX genes underlie human genetic diseases, cancer, and/or aging. In this review, we provide an updated overview of the main characteristics of the members of this family, in terms of breadth of expression, protein domain composition, evolution, and function.
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