Journal
TRENDS IN GENETICS
Volume 37, Issue 1, Pages 4-8Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tig.2020.10.007
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Funding
- Israel Science Foundation [119/16]
- Kekst Family Institute for Medical Genetics
- Israel Ministry of Science [Tashtiot (Infrastructures)] for Life Sciences and Biomedical Sciences [123402]
- Angel-Fiavovich grant for ecological research
- estate of Albert Engleman
- Benoziyo Endowment Fund for the Advancement of Science
- Rowland and Sylvia Career Development Chair
- Bi-institutional Kamin grant from the Research Innovation Authority
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For bacteria, the transition from unicellular entities to multicellular biofilm communities generates distinct metabolic microenvironments. Dynamic and programmed metabolic responses allow the biofilms to react to local changes in nutrient levels and contribute to phenotypic antibiotic resistance of the community. Novel therapeutic approaches targeting biofilms may stem from these metabolic adaptations.
For bacteria, the transition from unicellular entities to multicellular biofilm communities generates distinct metabolic microenvironments. Dynamic and programmed metabolic responses allow the biofilms to react to local changes in nutrient levels. Moreover, metabolic adaptations contribute to phenotypic antibiotic resistance of the community, suggesting novel therapeutic approaches to target biofilms.
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