Journal
TRENDS IN GENETICS
Volume 37, Issue 7, Pages 657-668Publisher
CELL PRESS
DOI: 10.1016/j.tig.2020.11.002
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Funding
- European Research Council (ERC) [757700]
- ERC [IR-DC (616434)]
- ICREA Research Professor program
- Severo Ochoa Centres of Excellence program
- Fondo Europeo de Desarrollo Regional (FEDER)/Ministerio de Ciencia, Innovacion y Universidades-Agencia Estatal de Investigacion [BFU2017-89488-P, BFU2017-89833P]
- Bettencourt Schueller Foundation
- Agencia de Gestio d'Ajuts Universitaris i de Recerca [2017 SGR 1322]
- Centres de Recerca de Catalunya (CERCA) program/Generalitat de Catalunya
- Spanish Ministry of Economy, Industry, and Competitiveness to the European Molecular Biology Laboratory (EMBL) partnership
- European Research Council (ERC) [757700] Funding Source: European Research Council (ERC)
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The nonsense-mediated mRNA decay (NMD) pathway has been extensively studied to accurately predict the degradation of mRNA with premature termination codons (PTCs). NMD plays a crucial role in disease identification and treatment, as well as in cancer immunotherapy.
The nonsense-mediated mRNA decay (NMD) pathway degrades some but not all mRNAs bearing premature termination codons (PTCs). Decades of work have elucidated the molecular mechanisms of NMD. More recently, statistical analyses of large genomic datasets have allowed the importance of known and novel 'rules of NMD' to be tested and combined into methods that accurately predict whether PTC-containing mRNAs are degraded or not. We discuss these genomic approaches and how they can be applied to identify diseases and individuals that may benefit from inhibition or activation of NMD. We also discuss the importance of NMD for gene editing and tumor evolution, and how inhibiting NMD may be an effective strategy to increase the efficacy of cancer immunotherapy.
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