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CARM1/PRMT4: Making Its Mark beyond Its Function as a Transcriptional Coactivator

Journal

TRENDS IN CELL BIOLOGY
Volume 31, Issue 5, Pages 402-417

Publisher

CELL PRESS
DOI: 10.1016/j.tcb.2020.12.010

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Funding

  1. Institut Curie
  2. European Union's Horizon 2020 Research and Innovation Programme (Marie Sklodowska-Curie grant) [666003]

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CARM1, originally identified as a coregulator of transcription, has been found to have novel roles in autophagy, metabolism, paraspeckles, and early development apart from its well-established involvement in transcriptional coactivation. It is also gaining attention as a promising therapeutic target and drug response biomarker in certain types of cancer.
Coactivator-associated arginine methyltransferase 1 (CARM1), identified 20 years ago as a coregulator of transcription, is an enzyme that catalyzes arginine methylation of proteins. Beyond its well-established involvement in the regulation of transcription, the physiological functions of CARM1 are still poorly understood. However, recent studies have revealed novel roles of CARM1 in autophagy, metabolism, paraspeckles, and early development. In addition, CARM1 is emerging as an attractive therapeutic target and a drug response biomarker for certain types of cancer. Here, we provide a comprehensive overview of the structure of CARM1 and its post-translational modifications, its various functions, apart from transcriptional coactivation, and its involvement in cancer.

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