Topological Twists in Nature

The first entangled protein was observed about 30 years ago, resulting in an increased interest for uncovering the biological functions and biophysical properties of these complex topologies. Recently, the Pierced Lasso Topology (PLT) was discovered in which a covalent bond forms an intramolecular loop, leaving one or both termini free to pierce the loop. This topology is related to knots and other entanglements. PLTs exist in many well-researched systems where the PLTs have previously been unnoticed. PLTs represents 18% of all disulfide containing proteins across all kingdoms of life. In this review, we investigate the biological implications of this specific topology in which the PLT-forming disulfide may act as a molecular switch for protein function and consequently human health.

Automated summary

The discovery of tangled proteins increased interest in uncovering biological functions and biophysical properties of complex topologies. The Pierced Lasso Topology (PLT) was recently discovered, representing 18% of disulfide containing proteins across all kingdoms of life. PLTs may act as molecular switches for protein function, impacting human health.