Journal
TRANSPLANT INFECTIOUS DISEASE
Volume 23, Issue 3, Pages -Publisher
WILEY
DOI: 10.1111/tid.13542
Keywords
CAR‐ T cell therapy; H275Y; lung transplant; lymphoma; neuraminidase inhibitor
Categories
Funding
- National Health and Medical Research Council [APP1176324, APP1169514]
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Limited treatment options are available for oseltamivir-resistant influenza, with baloxavir being proposed as a potentially effective alternative. Clinical experience with baloxavir in immunocompromised patients is still lacking, and further research is needed in this area.
Few treatment options are available for oseltamivir-resistant influenza. It has been proposed that baloxavir can be effective in this setting due to its distinct mechanism of action but clinical experience is lacking for immunocompromised patients. We report two such cases treated with baloxavir after failure of oseltamivir and detection of oseltamivir resistance mutations. Baloxavir/zanamivir combination therapy was effective in one patient, but persistent viral shedding was noted with baloxavir monotherapy in the other patient.
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