Journal
TRANSBOUNDARY AND EMERGING DISEASES
Volume 69, Issue 2, Pages 297-307Publisher
WILEY-HINDAWI
DOI: 10.1111/tbed.13978
Keywords
animal model; coronavirus; COVID-19; electron microscopy; ex vivo; ferret; in vitro; in vivo; SARS-CoV-2; TEM
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Funding
- Coalition for Epidemic Preparedness Innovations (CEPI)
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Researchers made efforts early in the SARS-CoV-2 outbreak to propagate and characterize an Australian isolate of the virus in vitro and in an ex vivo model of human airway epithelium, as well as to demonstrate the susceptibility of domestic ferrets to SARS-CoV-2 infection following intranasal challenge.
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is an emerging virus that has caused significant human morbidity and mortality since its detection in late 2019. With the rapid emergence has come an unprecedented programme of vaccine development with at least 300 candidates under development. Ferrets have proven to be an appropriate animal model for testing safety and efficacy of SARS-CoV-2 vaccines due to quantifiable virus shedding in nasal washes and oral swabs. Here, we outline our efforts early in the SARS-CoV-2 outbreak to propagate and characterize an Australian isolate of the virus in vitro and in an ex vivo model of human airway epithelium, as well as to demonstrate the susceptibility of domestic ferrets (Mustela putorius furo) to SARS-CoV-2 infection following intranasal challenge.
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