Journal
TRANSBOUNDARY AND EMERGING DISEASES
Volume 68, Issue 4, Pages 1868-1885Publisher
WILEY-HINDAWI
DOI: 10.1111/tbed.13907
Keywords
animal model; ferret; hamster; macaque; mice; pathophysiology; SARS‐ CoV‐ 2
Categories
Funding
- National Institute of Allergy and Infectious Diseases [R01 AI129745, 5P30 CA036727-33]
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Emerging and re-emerging viral diseases can have devastating effects on human lives and economies. Efforts in understanding SARS-CoV-2 biology for vaccine development and therapeutic interventions are intensifying globally. Animal models that mimic human SARS-CoV-2 infection are crucial for studying the pathophysiology of the virus.
Emerging and re-emerging viral diseases can create devastating effects on human lives and may also lead to economic crises. The ongoing COVID-19 pandemic due to the novel coronavirus (nCoV), severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which originated in Wuhan, China, has caused a global public health emergency. To date, the molecular mechanism of transmission of SARS-CoV-2, its clinical manifestations and pathogenesis is not completely understood. The global scientific community has intensified its efforts in understanding the biology of SARS-CoV-2 for development of vaccines and therapeutic interventions to prevent the rapid spread of the virus and to control mortality and morbidity associated with COVID-19. To understand the pathophysiology of SARS-CoV-2, appropriate animal models that mimic the biology of human SARS-CoV-2 infection are urgently needed. In this review, we outline animal models that have been used to study previous human coronaviruses (HCoVs), including severe acute respiratory syndrome coronavirus (SARS-CoV) and middle east respiratory syndrome coronavirus (MERS-CoV). Importantly, we discuss models that are appropriate for SARS-CoV-2 as well as the advantages and disadvantages of various available methods.
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