Journal
TOXICOLOGY IN VITRO
Volume 69, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tiv.2020.104990
Keywords
Skin absorption; Skin penetration; Partition coefficient; Diffusion coefficient; Infinite dose
Categories
Funding
- Cosmetics Europe
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A standard protocol was used to determine partition (K) and diffusion (D) coefficients in dermatomed human skin and isolated human skin layers for 50 compounds relevant to cosmetics ingredients. K values were measured in dermatomed skin, isolated dermis, whole epidermis, intact stratum corneum (SC), delipidized SC and SC lipids by direct measurements of the radioactivity in the tissue layers/lipid component vs. buffer samples. D determinations were made in dermatomed skin, isolated dermis, whole epidermis and intact SC using a non-linear regression of the cumulative receptor fluid content of radiolabeled compound, fit to the solution of Fick's 2nd Law. Correlation analysis was completed between K, D, and physicochemical properties. The amount of interindividual (donor) and intra-individual (replicate) variability in the K and D data was characterized for each skin layer and chemical. These data can be further used to help improve in silico models of dermal penetration.
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