Journal
THORAX
Volume 76, Issue 4, Pages 402-404Publisher
BMJ PUBLISHING GROUP
DOI: 10.1136/thoraxjnl-2020-216308
Keywords
interstitial fibrosis; lung physiology; respiratory infection
Categories
Funding
- Michael Smith Foundation for Health Research
- TB Vets charitable foundation
- Vancouver Coastal Health Research Institute
- University of British Columbia's Strategic Investment Fund
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The long-term respiratory morbidity of COVID-19 remains unclear. A study found that a significant percentage of previously hospitalized patients had persisting abnormalities in clinical, radiological, and pulmonary function, highlighting the importance of developing treatment strategies and long-term respiratory follow-up.
The long-term respiratory morbidity of COVID-19 remains unclear. We describe the clinical, radiological and pulmonary function abnormalities that persist in previously hospitalised patients assessed 12 weeks after COVID-19 symptom onset, and identify clinical predictors of respiratory outcomes. At least one pulmonary function variable was abnormal in 58% of patients and 88% had abnormal imaging on chest CT. There was strong association between days on oxygen supplementation during the acute phase of COVID-19 and both DLCO-% (diffusion capacity of the lung for carbon monoxide) predicted and total CT score. These findings highlight the need to develop treatment strategies and the importance of long-term respiratory follow-up after hospitalisation for COVID-19.
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