Journal
TETRAHEDRON
Volume 77, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2020.131742
Keywords
[3+3] cyclization; 2-Indolylmethanol; Quinone imine; Indole
Categories
Funding
- National Natural Science Foundation of China [21971256, 21977118, 81773584]
- National Science AMP
- Technology Major Project Key New Drug Creation and Manufacturing Program, China [2019ZX09301-151]
- Jiangsu Provincial Key Research and Development Project [BE2018710]
- Program for Jiangsu Province Innovative Research Team
- Double First-Class University project [CPU2018GY01, CPU2018GY35, CPU2018GY45]
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A formal [3 + 3] cyclization reaction between 2-indolylmethanols and quinones was achieved, resulting in the formation of indole-fused scaffolds with moderate to excellent yields. The protocol proceeded smoothly under acidic conditions, showing high yields and a broad substrate scope.
A formal [3 + 3] cyclization reaction of 2-indolylmethanols with quinones was realized to furnish indole-fused scaffolds in moderate to excellent yields. This protocol was proceeded smoothly under acid condition, with high high yields and broad substrate scope. (C) 2020 Elsevier Ltd. All rights reserved.
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