Journal
SYNTHESIS-STUTTGART
Volume 53, Issue 11, Pages 1879-1888Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/a-1360-7798
Keywords
flow microreactors; cross-coupling; reaction integration; aryl metals; flow synthesis
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This short review covers various aryl-aryl cross-coupling reactions carried out in flow, focusing on the metal species of the aryl nucleophiles used.
Aryl-aryl cross-coupling reactions are important reactions for the production of various biaryl compounds. This short review covers the various aryl-aryl cross-coupling reactions carried out in flow, focusing on the metal species of the aryl nucleophiles used in the cross-coupling reactions. 1 Introduction 2 Suzuki-Miyaura Coupling (B) 3 Migita-Kosugi-Stille Coupling (Sn) 4 Negishi Coupling (Zn) 5 Kumada-Tamao-Corriu Coupling (Mg) 6 Murahashi Coupling (Li) 7 Conclusion
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