Nickel-Catalyzed C-F/N-H Annulation of 2-(2-Fluoroaryl) N-Heteroaromatic Compounds with Alkynes: Activation of C-F Bonds

The reaction of 2-(2-fluoroaryl) N-heteroaromatic compounds, such as benzimidazole and indole derivatives, with internal alkynes in the presence of a catalytic amount of a nickel complex results in C-F/N-H annulation with alkynes. The reaction shows a high functional group compatibility. The presence of a strong base, such as KOBut or LiOBut, is required for the reaction to proceed.

Automated summary

The reaction involves annulation of 2-(2-fluoroaryl) N-heteroaromatic compounds with internal alkynes in the presence of a catalytic amount of a nickel complex. It shows high functional group compatibility and requires the presence of a strong base, such as KOBut or LiOBut, for the reaction to proceed.