Journal
SYNTHESIS-STUTTGART
Volume 53, Issue 9, Pages 1645-1653Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0040-1706602
Keywords
cobalt; vitamin B12; radical cyclization; Giese addition
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Funding
- Foundation for Polish Sciences (FNP TEAM) [POIR.04.04.00-00-4232/17-00]
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Vitamin B-12 plays a crucial role as a catalyst in organic reactions, facilitating the dicarbofuntionalization of bromoalkenes with electrophilic olefins to yield substituted pyrrolidines and piperidines efficiently.
Vitamin B-12 plays a crucial role in enzymatic transformations. This natural compound proved also useful as a catalyst in numerous organic reactions. Commercial availability and lower cost than precious metal complexes, make cobalamin an attractive candidate for a broader use as a benign Co-catalyst. Herein, the vitamin B-12-catalyzed dicarbofuntionalization of bromoalkenes with electrophilic olefins is reported leading to substituted pyrrolidines and piperidines in decent yields after only 15 minutes under light irradiation.
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