Catalytic Hydrogen Isotope Exchange Reactions in Late-Stage Functionalization

The introduction of deuterium and tritium into molecules is of great importance in drug discovery. Many attempts have been made to develop late-stage hydrogen isotope exchange (HIE) reactions to avoid multistep syntheses using commercially available labeled precursors. In this review, we summarize recent progress in catalytic HIE reactions, with our main focus on their applications in the late-stage labeling of bioactive complex molecules and pharmaceuticals1 Introduction

Automated summary

Introducing deuterium and tritium into molecules is crucial for drug discovery. Recent advancements in catalytic HIE reactions have provided efficient methods for late-stage labeling of bioactive complex molecules and pharmaceuticals, avoiding multistep syntheses.