Journal
SURFACE & COATINGS TECHNOLOGY
Volume 406, Issue -, Pages -Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.surfcoat.2020.126644
Keywords
Layer-by-layer; Composite dressing; Hemostasis; Wound healing
Funding
- National Natural Science Foundation of China [51873195, 51573167]
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A hemostatic material was developed by successively constructing carboxymethyl chitosan (CMC), gelatin, and alginate onto a cotton gauze surface through a layer-by-layer process, demonstrating high fluid absorption, excellent biocompatibility, and hemocompatibility. Animal tests showed better hemostatic performance compared to cotton gauze, with a significant promotion effect on wound healing demonstrated in a mouse defect wound model.
We developed a hemostatic material able to quickly stop wound bleeding by successively constructing carboxymethyl chitosan (CMC), gelatin, and alginate onto a cotton gauze surface through a simple layer-by-layer (LbL) process. Briefly, we grafted CMC onto the cotton fibers through an esterification reaction with the hydroxyl groups of the cellulose chains, and then built a gelatin layer on the CMC layer by the ionic reactions with CMC. Finally, we integrated alginate by the lamellar structure through the cross-linking reactions caused by the Ca2+ ions permeated from the gelatin layer. Characterization analyses demonstrated that the resulting composite dressing possessed high fluid absorption, excellent biocompatibility, and hemocompatibility. A better hemostatic performance was also revealed in animal tests compared with cotton gauze, and it showed a short hemostasis time and a small amount of blood loss in the mouse liver injury model and mouse-tail amputation model. Moreover, the composite dressing also exhibited a significant promotion effect of wound healing in a mouse defect wound model. This new composite dressing, which was prepared by natural raw materials, is a promising candidate for wound dressing and demonstrated great potential in medical applications.
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