Journal
STEM CELL RESEARCH
Volume 50, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.scr.2020.102118
Keywords
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Funding
- Australian National Health & Medical Research Council [GNT 1146902]
- Victorian Government's Operational Infrastructure Support Program
- Murdoch Children's Research Institute Strategic Pilot project grant/Stafford Fox Medical Research Foundation
- Stafford Fox Medical Research Foundation
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miR-26b is implicated in various human diseases, and a homozygous miR-26b stem-loop knockout human iPSC line has been generated and characterized in this study. This gene-edited iPSC line exhibits normal karyotype, pluripotency markers, and differentiation potential, making it valuable for investigating disease mechanisms and therapeutic strategies in vitro.
miR-26b has been implicated in a wide range of human diseases, including cancer, diabetes, heart disease, Alzheimer's disease and osteoarthritis. To provide a tool to explore the importance of miR-26b in this broad context, we have generated and characterized a homozygous miR-26b stem-loop knockout human iPSC line. This gene-edited line exhibited a normal karyotype, expressed pluripotency markers and differentiated into cells representative of the three embryonic germ layers. This iPSC line will be valuable for studies investigating disease mechanisms and testing therapeutic strategies in vitro.
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