Journal
SEPARATION AND PURIFICATION TECHNOLOGY
Volume 255, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.seppur.2020.117728
Keywords
1,2,4-Butanetriol; Phenylboronic acid derivatives; Reactive extraction; Fermentation broths
Categories
Funding
- National Natural Science Foundation of China [21922814, 21676273, 21961160745, 31961133019, 21921005]
- Beijing Municipal Natural Science Foundation [2194086]
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Effective isolation of 1,2,4-butanetriol from fermentation broth with low concentrations was achieved through anionic reactive extraction using a boronic acid carrier and A336 dissolved in the organic phase. The study explored the impact of various factors on extraction efficiency and successfully concentrated 1,2,4-butanetriol by 4.6 times compared to the original fermentation broth.
Effective isolation of 1,2,4-butanetriol (BT) from the fermentation broth with low BT concentration was achieved based on anionic reactive extraction with a combined extractant consisted of boronic acid carrier and tri-octylmetylammonium Aliquot (R) 336 (A336) dissolved in the organic phase. The influence of various diluents, pH values, the ratio of phenylbomnic acid derivatives (PBAD) to BT (alpha(PBAD/BT)), and A336 to BT (beta(A336/BT)) on extraction property was investigated in detail. For model BT solutions, satisfactory extraction efficiency of 92% was obtained under the conditions of alpha(PBAD/BT) = 1.5, beta(A336/BT) = 2, with dichlommethane as a diluent. Aqueous hydrochloric acid solutions were employed to strip BT from the organic phase. For actual fermentation broth, the extraction and stripping efficiency under the optimum conditions were 74% and 69%, respectively. Besides, compared with the original fermentation broth, 1,2,4-butanetriol has been concentrated by 4.6 times with the reactive extraction coupled hydrolysis.
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