Journal
SENSORS AND ACTUATORS B-CHEMICAL
Volume 327, Issue -, Pages -Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2020.128943
Keywords
Surface-enhanced Raman scattering; hydrogel micropellets; pretreatment-free; blood glucose; melamine
Funding
- National Natural Science Foundation of China [21873039]
- China Scholar-ship Council
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A universal SERS-hydrogel micropellet was developed for reliable detections of glucose and melamine in complex samples without the need for pretreatment. The micropellets have adjustable pore size selectivity, allowing for highly selective SERS determinations of small molecules. This method simplifies the operation, provides quick response times, and is cost-effective.
The detections of significant small molecules in biological fluids is always challenging due to the complicated sample pretreatment. Here, a universal SERS-hydrogel micropellet was developed for pretreatment-free, reliable detections of small molecules (glucose and melamine) in complex sample (whole blood and milk). The SERS-hydrogel micropellet has an adjustable pore size, which is acquired by the ultraviolet light solidification of the water-in-oil microdroplets in which the hydrogel monomers and the SERS-active metal nanoparticles (MNPs) were encapsulated. These micropellets have a pore size selectivity to allow small molecules to access in and exclude larger molecules, which is helpful for the highly selective, label-free/labeling SERS determinations of small molecules. This SERS substrate ensures high reproducibility of SERS detections since MNPs are uniformly dispersed in each micropellet. The hydrogel matrix can well protect MNPs from the surrounding environments to guarantee long-term stability. The lowest detectable concentration is 10 mu M for glucose in whole blood and 10 nM for melamine in milk, and the linear ranges are 0.1-20 mM and 10(-8)-10(-3) M, respectively. This method avoids the complicated preprocessing steps, requires a small volume of samples, has a fast response time and lowcost, which provides the possibility for multiplex SERS detections in liquid biopsy.
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