Journal
SENSORS
Volume 21, Issue 1, Pages -Publisher
MDPI
DOI: 10.3390/s21010102
Keywords
paper-based devices; paper microfluidics; colorimetric assay; nitrate detection; nitrite detection; Griess reaction; zinc microparticles; point-of-care diagnostics; sensors; low-cost platforms
Funding
- National Science Foundation under EPSCoR Cooperative Agreement [OIA-1655221]
Ask authors/readers for more resources
The paper presents a simple and cost-effective paper-based microfluidic device for detecting nitrate in water. By incorporating recent advancements in paper-based technology suitable for nitrate detection, the device achieved significant improvement in nitrate detection compared to previous methods.
In this paper, we report a simple and inexpensive paper-based microfluidic device for detecting nitrate in water. This device incorporates two recent developments in paper-based technology suitable for nitrate detection and has an optimized microfluidic design. The first technical advancement employed is an innovative fibrous composite material made up of cotton fibers and zinc microparticles that can be incorporated in paper-based devices and results in better nitrate reduction. The second is a detection zone with an immobilized reagent that allows the passage of a larger sample volume. Different acids were tested-citric and phosphoric acids gave better results than hydrochloric acid since this acid evaporates completely without leaving any residue behind on paper. Different microfluidic designs that utilize various fluid control technologies were investigated and a design with a folding detection zone was chosen and optimized to improve the uniformity of the signal produced. The optimized design allowed the device to achieve a limit of detection and quantification of 0.53 ppm and 1.18 ppm, respectively, for nitrate in water. This accounted for more than a 40% improvement on what has been previously realized for the detection of nitrate in water using paper-based technology.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available