Journal
E-POLYMERS
Volume 16, Issue 5, Pages 351-358Publisher
WALTER DE GRUYTER GMBH
DOI: 10.1515/epoly-2016-0138
Keywords
biocompatibility; electrospinning; freeze-drying; morphology; polymer membranes
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Funding
- Faculty of Materials Science and Ceramics, AGH University of Science and Technology, Krakow, Poland [11.11.160.616]
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The aim of this work was to develop bioresorbable, asymmetric membranes for guided bone regeneration (GBR). Two resorbable polymers - polylactide (PLA) and polycaprolactone (PCL) were used in fabrication process. Two different manufacturing methods were applied: electrospinning in the case of PLA and freeze-drying of PCL. Mechanical properties, stability in a water environment and biocompatibility of fabricated membranes were evaluated. Microstructure [scanning electron microscopy (SEM)] of the membranes was assessed in terms of level of porosity, as well as size and shape of the pores. Study showed that combination of electrospinning and freeze-drying methods allows biocompatible PLA/PCL bi-phasic materials of appropriate mechanical properties and diverse microstructure to be produced, that should on the one hand prevent soft tissue growth, and on the other hand be a suitable scaffold for the growth of bone cells.
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