Non-coding RNAs rewire cancer metabolism networks

Non-coding RNAs (ncRNAs) are functional RNAs with limited or no protein-coding ability. These interact with their target molecules and participate in the precise regulation of disease development. Metabolic reprogramming is a hallmark in cancer, and is considered essential in meeting increased macromolecular biosynthesis and energy generation of tumors. Recent studies have revealed the involvement of ncRNAs in several metabolic regulations of cancer through direct modulation of metabolic enzyme activities or participation of metabolismrelated signaling pathways. Elucidation of how ncRNAs regulate metabolic reprogramming of cancers has opened up a novel intention to understand the mechanism of metabolic rewiring and also the opportunities of utilizing ncRNA-based therapeutics for targeting the metabolism in cancer treatment.

Automated summary

Non-coding RNAs are functional RNAs that play a role in regulating disease development, particularly in cancer metabolic reprogramming. They can influence cancer metabolism regulation by directly modulating metabolic enzyme activities or participating in metabolism-related signaling pathways.