Related references
Note: Only part of the references are listed.Interleukin-2 druggability is modulated by global conformational transitions controlled by a helical capping switch
Viviane S. De Paula et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)
Interleukin-2 signals converge in a lymphoid-dendritic cell pathway that promotes anticancer immunity
Miro E. Raeber et al.
SCIENCE TRANSLATIONAL MEDICINE (2020)
Human FOXP3+ Regulatory T Cell Heterogeneity and Function in Autoimmunity and Cancer
James B. Wing et al.
IMMUNITY (2019)
IL-4 receptor engagement in human neutrophils impairs their migration and extracellular trap formation
Daniela Impellizzieri et al.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2019)
The γc Family of Cytokines: Basic Biology to Therapeutic Ramifications
Warren J. Leonard et al.
IMMUNITY (2019)
Immunological and clinical effects of low-dose interleukin-2 across 11 autoimmune diseases in a single, open clinical trial
Michelle Rosenzwajg et al.
ANNALS OF THE RHEUMATIC DISEASES (2019)
De novo design of potent and selective mimics of IL-2 and IL-15
Daniel-Adriano Silva et al.
NATURE (2019)
Low-dose interleukin-2 therapy in refractory systemic lupus erythematosus: an investigator-initiated, single-centre phase 1 and 2a clinical trial
Jens Y. Humrich et al.
LANCET RHEUMATOLOGY (2019)
The role of cytokines in T-cell memory in health and disease
Miro E. Raeber et al.
IMMUNOLOGICAL REVIEWS (2018)
A human anti-IL-2 antibody that potentiates regulatory T cells by a structure-based mechanism
Eleonora Trotta et al.
NATURE MEDICINE (2018)
Engineering a Single-Agent Cytokine/Antibody Fusion That Selectively Expands Regulatory T Cells for Autoimmune Disease Therapy
Jamie B. Spangler et al.
JOURNAL OF IMMUNOLOGY (2018)
Regulatory T cells in the treatment of disease
Amir Sharabi et al.
NATURE REVIEWS DRUG DISCOVERY (2018)
Regulation of Effector and Memory CD8 T Cell Differentiation by IL-2-A Balancing Act
Vandana Kalia et al.
FRONTIERS IN IMMUNOLOGY (2018)
Signaling and Function of Interleukin-2 in T Lymphocytes
Sarah H. Ross et al.
ANNUAL REVIEW OF IMMUNOLOGY, VOL 36 (2018)
Revisiting IL-2: Biology and therapeutic prospects
Abul K. Abbas et al.
SCIENCE IMMUNOLOGY (2018)
IL-2/anti-IL-2 complexes ameliorate lupus nephritis by expansion of CD4+CD25+Foxp3+ regulatory T cells
Ji-Jing Yan et al.
KIDNEY INTERNATIONAL (2017)
Efficacy, durability, and response predictors of low-dose interleukin-2 therapy for chronic graft-versus-host disease
John Koreth et al.
BLOOD (2016)
Type 2 Interleukin-4 Receptor Signaling in Neutrophils Antagonizes Their Expansion and Migration during Infection and Inflammation
Janine Woytschak et al.
IMMUNITY (2016)
Improved cancer immunotherapy by a CD25-mimobody conferring selectivity to human interleukin-2
Natalia Arenas-Ramirez et al.
Science Translational Medicine (2016)
The Highly Evolvable Antibody Fc Domain
Hye In Park et al.
TRENDS IN BIOTECHNOLOGY (2016)
Rapid induction of clinical remission by low-dose interleukin-2 in a patient with refractory SLE
Jens Y. Humrich et al.
ANNALS OF THE RHEUMATIC DISEASES (2015)
Selective IL-2 Responsiveness of Regulatory T Cells Through Multiple Intrinsic Mechanisms Supports the Use of Low-Dose IL-2 Therapy in Type 1 Diabetes
Aixin Yu et al.
DIABETES (2015)
Antibodies to Interleukin-2 Elicit Selective T Cell Subset Potentiation through Distinct Conformational Mechanisms
Jamie B. Spangler et al.
IMMUNITY (2015)
interleukin-2: Biology, Design and Application
Natalia Arenas-Ramirez et al.
TRENDS IN IMMUNOLOGY (2015)
Regulatory T cells and immune regulation of allergic diseases: roles of IL-10 and TGF-β
O. Palomares et al.
GENES AND IMMUNITY (2014)
IL-2: The First Effective Immunotherapy for Human Cancer
Steven A. Rosenberg
JOURNAL OF IMMUNOLOGY (2014)
Regulatory T cells suppress muscle inflammation and injury in muscular dystrophy
S. Armando Villalta et al.
SCIENCE TRANSLATIONAL MEDICINE (2014)
How good are my data and what is the resolution?
Philip R. Evans et al.
ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY (2013)
Low-Dose Interleukin-2 Therapy Restores Regulatory T Cell Homeostasis in Patients with Chronic Graft-Versus-Host Disease
Ken-ichi Matsuoka et al.
SCIENCE TRANSLATIONAL MEDICINE (2013)
Low-dose interleukin 2 in patients with type 1 diabetes: a phase 1/2 randomised, double-blind, placebo-controlled trial
Agnes Hartemann et al.
LANCET DIABETES & ENDOCRINOLOGY (2013)
Towards automated crystallographic structure refinement with phenix.refine
Pavel V. Afonine et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2012)
Cytokine Therapy With Interleukin-2/Anti-Interleukin-2 Monoclonal Antibody Complexes Expands CD4+CD25+Foxp3+ Regulatory T Cells and Attenuates Development and Progression of Atherosclerosis
Tam Nguyen Dinh et al.
CIRCULATION (2012)
Interleukin-2/anti-interleukin-2 monoclonal antibody immune complex suppresses collagen-induced arthritis in mice by fortifying interleukin-2/STAT5 signalling pathways
Seon-Yeong Lee et al.
IMMUNOLOGY (2012)
Impact of Interleukin-2-expanded Regulatory T Cells in Various Allogeneic Combinations on Mouse Skin Graft Survival
B. Vokaer et al.
TRANSPLANTATION PROCEEDINGS (2012)
Application of IL-2 therapy to target T regulatory cell function
Ethan M. Shevach
TRENDS IN IMMUNOLOGY (2012)
The role of interleukin-2 during homeostasis and activation of the immune system
Onur Boyman et al.
NATURE REVIEWS IMMUNOLOGY (2012)
REFMAC5 for the refinement of macromolecular crystal structures
Garib N. Murshudov et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2011)
Regulatory T-Cell Responses to Low-Dose Interleukin-2 in HCV-Induced Vasculitis
David Saadoun et al.
NEW ENGLAND JOURNAL OF MEDICINE (2011)
Interleukin-2 and Regulatory T Cells in Graft-versus-Host Disease
John Koreth et al.
NEW ENGLAND JOURNAL OF MEDICINE (2011)
Features and development of Coot
P. Emsley et al.
ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY (2010)
Expansion of regulatory T cells via IL-2/anti-IL-2 mAb complexes suppresses experimental myasthenia
Ruolan Liu et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2010)
Prolonged Interleukin-2Rα Expression on Virus-Specific CD8+ T Cells Favors Terminal-Effector Differentiation In Vivo
Vandana Kalia et al.
IMMUNITY (2010)
High content cellular immune profiling reveals differences between rhesus monkeys and men
Isabelle Magalhaes et al.
IMMUNOLOGY (2010)
IL-2/anti-IL-2 antibody complexes show strong biological activity by avoiding interaction with IL-2 receptor α subunit CD25
Sven Letourneau et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Improved IL-2 immunotherapy by selective stimulation of IL-2 receptors on lymphocytes and endothelial cells
Carsten Krieg et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
In vivo expansion of T reg cells with IL-2-mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression
Kylie E. Webster et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2009)
Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction
Qizhi Tang et al.
IMMUNITY (2008)
In vivo switch to IL-10-secreting T regulatory cells in high dose allergen exposure
Flurina Meiler et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2008)
IL-7/Anti-IL-7 mAb complexes restore T cell development and induce homeostatic T cell expansion without lymphopenia
Onur Boyman et al.
JOURNAL OF IMMUNOLOGY (2008)
Characterization of naturally occurring CD4+CD25+ regulatory T cells in rhesus monkeys
Krista G. Haanstra et al.
TRANSPLANTATION (2008)
Inference of macromolecular assemblies from crystalline state
Evgeny Krissinel et al.
JOURNAL OF MOLECULAR BIOLOGY (2007)
The impact of glycosylation on the biological function and structure of human immunoglobulins
James N. Arnold et al.
ANNUAL REVIEW OF IMMUNOLOGY (2007)
Selective stimulation of T cell subsets with antibody-cytokine immune complexes
O Boyman et al.
SCIENCE (2006)
Crystal structure of the IL-2 signaling complex: Paradigm for a heterotrimeric cytokine receptor
DJ Stauber et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Structure of the quaternary complex of interleukin-2 with its α, β, and γc receptors
XQ Wang et al.
SCIENCE (2005)
Binding of small molecules to an adaptive protein-protein interface
MR Arkin et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Share Paper
