Journal
SCIENCE TRANSLATIONAL MEDICINE
Volume 12, Issue 570, Pages -Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/scitranslmed.aay5445
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Funding
- NIH [R01 AI101018, DK113598, R01 DK110174, U41 AT008718]
- NSERC [RGPIN-2016-03962]
- HHMI-Simons Faculty Scholars Award
- Investigators in the Pathogenesis of Infectious Disease award from the Burroughs Wellcome Foundation
- Cleveland Clinic Foundation
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The composition of the skin microbiota varies widely among individuals when sampled at the same body site. A key question is which molecular factors determine strain-level variability within sub-ecosystems of the skin microbiota. Here, we used a genomics-guided approach to identify an antibacterial biosynthetic gene cluster in Cutibacterium acnes (formerly Propionibacterium acnes), a human skin commensal bacterium that is widely distributed across individuals and skin sites. Experimental characterization of this biosynthetic gene cluster resulted in identification of a new thiopeptide antibiotic, cutimycin. Analysis of individual human skin hair follicles revealed that cutimycin contributed to the ecology of the skin hair follicle microbiota and helped to reduce colonization of skin hair follicles by Staphylococcus species.
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