4.5 Article

Unlike LGR4, LGR5 potentiates Wnt-β-catenin signaling without sequestering E3 ligases

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Differential activities and mechanisms of the four R-spondins in potentiating Wnt/-catenin signaling

Soohyun Park et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2018)

Article Biology

R-spondins can potentiate WNT signaling without LGRs

Andres M. Lebensohn et al.

ELIFE (2018)

Article Biochemistry & Molecular Biology

LGR5 receptor promotes cell-cell adhesion in stem cells and colon cancer cells via the IQGAP1-Rac1 pathway

Kendra S. Carmon et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2017)

Article Biochemistry & Molecular Biology

Inhibiting clathrin-mediated endocytosis of the leucine-rich G protein-coupled receptor-5 diminishes cell fitness

Joshua C. Snyder et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2017)

Review Pharmacology & Pharmacy

Assembly and architecture of the Wnt/β-catenin signalosome at the membrane

Zachary J. DeBruine et al.

BRITISH JOURNAL OF PHARMACOLOGY (2017)

Article Biochemistry & Molecular Biology

Crystal structure of R-spondin 2 in complex with the ectodomains of its receptors LGR5 and ZNRF3

Matthias Zebisch et al.

JOURNAL OF STRUCTURAL BIOLOGY (2015)

Article Pharmacology & Pharmacy

Engineering High-Potency R-spondin Adult Stem Cell Growth Factors

Margaret L. Warner et al.

MOLECULAR PHARMACOLOGY (2015)

Article Developmental Biology

Functional roles of Lgr4 and Lgr5 in embryonic gut, kidney and skin development in mice

Bernd Kinzel et al.

DEVELOPMENTAL BIOLOGY (2014)

Article Gastroenterology & Hepatology

Stem Cells Marked by the R-Spondin Receptor LGR5

Bon-Kyoung Koo et al.

GASTROENTEROLOGY (2014)

Review Cell Biology

The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength

Wim de Lau et al.

GENES & DEVELOPMENT (2014)

Letter Biochemical Research Methods

Improved vectors and genome-wide libraries for CRISPR screening

Neville E. Sanjana et al.

NATURE METHODS (2014)

Article Multidisciplinary Sciences

RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling

Kendra S. Carmon et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Multidisciplinary Sciences

RSPO2-LGR5 signaling has tumour-suppressive activity in colorectal cancer

Changjie Wu et al.

NATURE COMMUNICATIONS (2014)

Article Cell Biology

The structural basis of R-spondin recognition by LGR5 and RNF43

Po-Han Chen et al.

GENES & DEVELOPMENT (2013)

Article Cell Biology

Structural basis for R-spondin recognition by LGR4/5/6 receptors

Dongli Wang et al.

GENES & DEVELOPMENT (2013)

Article Biochemistry & Molecular Biology

Constitutive Internalization of the Leucine-rich G Protein-coupled Receptor-5 (LGR5) to the Trans-Golgi Network

Joshua C. Snyder et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

Article Multidisciplinary Sciences

Analysis of LGR4 Receptor Distribution in Human and Mouse Tissues

Jing Yi et al.

PLOS ONE (2013)

Article Biochemistry & Molecular Biology

Crystal Structures of Lgr4 and Its Complex with R-Spondin1

Kai Xu et al.

STRUCTURE (2013)

Article Biochemistry & Molecular Biology

LGR5 Interacts and Cointernalizes with Wnt Receptors To Modulate Wnt/β-Catenin Signaling

Kendra S. Carmon et al.

MOLECULAR AND CELLULAR BIOLOGY (2012)

Article Multidisciplinary Sciences

ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner

Huai-Xiang Hao et al.

NATURE (2012)

Article Multidisciplinary Sciences

R-Spondin Potentiates Wnt/β-Catenin Signaling through Orphan Receptors LGR4 and LGR5

Heinz Ruffner et al.

PLOS ONE (2012)

Article Multidisciplinary Sciences

Wnt pathway inhibition via the targeting of Frizzled receptors results in decreased growth and tumorigenicity of human tumors

Austin Gurney et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Biochemistry & Molecular Biology

Lgr4 is required for Paneth cell differentiation and maintenance of intestinal stem cells ex vivo

Roxana C. Mustata et al.

EMBO REPORTS (2011)

Article Biochemistry & Molecular Biology

LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signalling

Andrei Glinka et al.

EMBO REPORTS (2011)

Article Multidisciplinary Sciences

Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

Wim de Lau et al.

NATURE (2011)

Article Multidisciplinary Sciences

R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/β-catenin signaling

Kendra S. Carmon et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Review Gastroenterology & Hepatology

Leucine-Rich Repeat-Containing G-Protein-Coupled Receptors as Markers of Adult Stem Cells

Nick Barker et al.

GASTROENTEROLOGY (2010)

Article Multidisciplinary Sciences

Identification of stem cells in small intestine and colon by marker gene Lgr5

Nick Barker et al.

NATURE (2007)

Article Biochemical Research Methods

Proximity ligation assays for sensitive and specific protein analyses

SM Gustafsdottir et al.

ANALYTICAL BIOCHEMISTRY (2005)

Article Cell Biology

Expression pattern of the orphan receptor LGR4/GPR48 gene in the mouse

G Van Schoore et al.

HISTOCHEMISTRY AND CELL BIOLOGY (2005)