Journal
SCIENCE OF THE TOTAL ENVIRONMENT
Volume 746, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.scitotenv.2020.141200
Keywords
WWTP; Pharmaceuticals; Antibiotics; Hazard quotient; Ecotoxicity; Latin America
Categories
Funding
- UCREA at Universidad de Costa Rica [802-B7-A09]
- Vicerrectoria de Investigacion at Universidad de Costa Rica [802-B8-510, 802-B8-144, 802B8-145]
- Ministerio de Ciencia, Tecnologia y Telecomunicaciones de Costa Rica (MICITT) [FI197B-17]
- MICITT [FI-056B-17]
- Consejo Nacional para Investigaciones Cientificas y Tecnologicas
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The continuous release of pharmaceuticals from WWTP effluents to freshwater is a matter of concern, due to their potential effects on non-target organisms. The occurrence of pharmaceuticals in WWTPs and their associated hazard have been scarcely studied in Latin American countries. This study aimed at monitoring for the first time the occurrence of 70 pharmaceutical active compounds (PhACs) in WWTPs across Costa Rica; the application of the hazard quotient (HQ) approach coupled to ecotoxicological determinations permitted to identify the hazard posed by specific pharmaceuticals and toxicity of the effluents, respectively. Thirty-three PhACs were found, with 1,7-dimethylxanthine, caffeine, acetaminophen, ibuprofen, naproxen, ketoprofen and gemfibrozil being the most frequently detected (influents/effluents). HQ for specific pharmaceuticals revealed 24 compounds with high/medium hazard in influents, while the amount only decreased to 21 in effluents. The top HQ values were obtained for risperidone, lovastatin, diphenhydramine and fluoxetine (influent/effluent samples), plus caffeine (influent) and trimethoprim (effluent). Likewise, the estimation of overall hazard in WWTP samples (sum of individual HQ, Sigma HQ) demonstrated that every influent and 96% of the effluents presented high hazard towards aquatic organisms. Ecotoxicological analysis (Daphnia magna, Lactuca sativa and Microtox test) revealed that 16.7% of the effluents presented toxicity towards all benchmark organisms; the phytotoxicity was particularly frequent, as inhibition values >= 20% in the germination index for L. sativa were obtained for all the effluents. The Sigma HQ approach estimated the highest hazard in urban wastewater, while the ecotoxicological results showed the highest toxicity in hospital and landfill wastewater. Likewise, ecotoxicological results and Sigma HQ values showed a rather poor correlation; instead, better correlations were obtained between ecotoxicological parameters and HQ values for some individual pharmaceuticals such as cephalexin and diphenhydramine. Findings from this study provide novel information on the occurrence of pharmaceuticals and the performance of WWTPs in the tropical region of Central America. (C) 2020 Elsevier B.V. All rights reserved.
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