Journal
SCIENCE CHINA-CHEMISTRY
Volume 64, Issue 4, Pages 558-564Publisher
SCIENCE PRESS
DOI: 10.1007/s11426-020-9920-x
Keywords
theranostics; holmium; dual-modality imaging; photothermal therapy
Categories
Funding
- National Natural Science Foundation of China [51502284, 21834007, 21521092, 21590794, 52022094, 21673220]
- Program of Science and Technology Development Plan of Jilin Province of China [20170101186JC]
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDB20030300]
- Youth Innovation Promotion Association of Chinese Academy of Sciences [2019232]
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Novel theranostic nanoagents, such as polydopamine-functionalized ammonium holmium fluoride nanocomposites (AHF@PDA), have shown promising results in both imaging diagnosis and cancer therapy, demonstrating great potential for future clinical application.
Limited to intrinsic defects of traditional treatment of cancer, it seems quite needed to construct novel theranostic nanoagents that can not only improve the accuracy of imaging diagnosis but also achieve highly efficient therapy of cancer. Herein, we fabricated polydopamine-functionalized ammonium holmium fluoride nanocomposites (AHF@PDA) for dual-modality bioimaging (magnetic resonance imaging (MRI) and computed tomography (CT)) owing to the high X-ray attenuation feature and magnetic property of Ho3+. Moreover, PDA shell endows AHF@PDA with excellent photothermal conversion performances and robust biocompatibility, leading to good treatment effect in vitro and in vivo. All above positive results certify that AHF@PDA have good potential as theranostic agents for clinical application in the future.
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