Journal
RNA BIOLOGY
Volume 18, Issue 5, Pages 647-656Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/15476286.2020.1862567
Keywords
Th17; mRNA stability; decay; rbps; miRNAs; lncRNAs; rna modifications; nmd; pathogenicity
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Funding
- National Natural Science Foundation of China [31670889, 31200668]
- National Key Research and Development Project [2016YFA0502203, 2016YFA0502204]
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This review summarizes the role of RNA-binding proteins, microRNAs, and long non-coding RNAs in regulating the fate of Th17 cells, as well as the impact of RNA modifications and nonsense-mediated mRNA decay in Th17 cells. Ongoing research may provide insights into practical applications for regulating mRNA stability in the context of Th17-related autoimmune diseases.
Th17 cells remain one of the most important subsets of T cells in numerous autoimmune and chronic inflammatory diseases. Posttranscriptional regulation (PTR), especially mRNA stability, has recently emerged as an important mechanism that controls the fate of Th17 cells. This review summarizes the current knowledge on RNA-binding proteins (RBPs), microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) that induce mRNA stability changes and their roles in mediating the differentiation, proliferation, function, and migration of Th17 cells. In addition, we summarize the role of RNA modifications and nonsense-mediated mRNA decay (NMD) in Th17 cells. Ongoing research will help to identify practical applications for the regulation of mRNA stability and provide potential targets to prevent and treat Th17-related autoimmune diseases.
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