Journal
DYES AND PIGMENTS
Volume 126, Issue -, Pages 239-250Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.dyepig.2015.12.009
Keywords
Charge reversal; Zinc phthalocyanines; Amino acids; Photodynamic therapy; Tumor microenvironment; Isoelectric pH
Funding
- National Natural Science Foundation of China [21201102]
- Natural Science Foundation of Jiangsu Higher Education Institutions of China [13KJA150003]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
- Jiangsu Collaborative Innovation Centre of Biomedical Functional Materials
- [1812000002131]
Ask authors/readers for more resources
Amino acid substituted zinc phthalocyanines which are capable of reversing their charge from negative to positive in response to tumor microenvironment have been prepared by the isoelectric pHs regulation and charge reversal sensitivity enhancement. The charge reversal abilities of the prepared zinc phthalocyanines were judged by their isoelectric pHs and zeta potential values. The UV-Vis spectra, singlet oxygen generation ability, cellular uptake and in vitro anticancer ability of the prepared zinc phthalocyanines were investigated to study the influences of charge reversal on photodynamic activities. Charge reversible tetra- and octa-substituted glutamic acid ZnPcs showed enhanced singlet oxygen generation ability, cellular uptake and photocytotoxicity towards cancer cells, and were considered as promising photosensitizers for photodynamic therapy. (C) 2015 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available